Meeting Banner
Abstract #0259

Assessment of Myocardial Radiofrequency Ablation Lesions with 3D High Resolution Free-Breathing T2 Mapping

Daniel A. Herzka1, Haiyan Ding2, 3, Farhad Pashakhanloo3, Karl H. Schuleri4, Aravindan Kolandaivelu4, Elliot R. McVeigh3, Henry Halperin5, M. Muz Zviman4, Roy Beinart4

1Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; 2Biomedical Engineering, Tsinghua University, Beijing, China; 3Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States; 4Department of Medicine, Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, United States; 5Department of Medicine, Cardiology, Johns Hopkins University, Baltimore, MD, United States

Radiofrequency ablation (RFA) has become first-line therapy for many cardiac arrhythmias. Differentiating between viable myocardium and injured tissue (necrosis or edema) in both ventricles and atria following RFA can help in predicting the recurrence of arrhythmias. High-resolution MR imaging techniques such as late gadolinium enhancement (LGE) are well-established for the delineation of lesions. More recently, quantitative techniques such as T2 mapping have been demonstrated for the evaluation of acute injury. Here we present, high-resolution, 3 dimensional (3D) whole-heart free-breathing T2 mapping for the post-procedural detection of RF ablation lesions and correlate the results to high-resolution in vivo LGE and ex vivo images.

Abstract PDF Presentation Video

Keywords

ablation acute agent animal animals apical applied approved arrhythmias arrow arrows assessment association axis basal become biomedical bottom boundary breathing buffered bull card cardiac cardiology china clearly clinical contrast controlled core correlate correlates correlation created creating dark datasets days decreased delineation depicted detected detection determine dimensional ding dose duration easily edema edematous engineering enhancing established exceeded excised excluding extent faded fashion fixed form formaldehyde free gadolinium generated goal heart hearts help henry hold hours identify immediately improve in vivo independently induced infusion initial injured injury interpolated interrupted inversion irrigated johns lesion lesions linear little long manually mapping maps medicine mode model myocardial necrosis necrotic part period plot post power predicting prep prepared procedure protocol quantitative recovery registered regression relevant remaining residual resolution sacrificed sample scale scar school segmented segments sensitive sensitivity separate sequential sessions significantly stir submerged sufficient surface surrounding system therapeutically tissue unloaded validate ventricle ventricles visible volume volumes wall whether whole