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Abstract #0254

Acute Hemorrhagic Myocardial Infarction Leads to Localized Chronic Iron Deposition: A CMR Study

Avinash Kali1, 2, Ivan Cokic1, Andreas Kumar3, Richard L Q Tang1, Sotirios A. Tsaftaris4, Matthias G. Friedrich5, Rohan Dharmakumar1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Department of Biomedical Engineering, University of California, Los Angeles, CA, United States; 3Qubec Heart and Lung Institute, Laval University, Qubec City, QC, Canada; 4Computer Science and Applications, IMT Institutions, Lucca, Italy; 5Montral Heart Institute, Universit de Montral, Montral, QC, Canada

The long-term fate of acute reperfusion intramyocardial hemorrhage (IMH) was studied using CMR. T2* maps and Late Gadolinium Enhancement images were acquired in patients with first STEMI at 3 days (acute) and 6 months (chronic) post-PCI, and in canines subjected to ischemia-reperfusion injury at 3 days (acute) and 56 days (chronic) post-reperfusion. Both patients and canines with acute IMH had persistent T2* losses within infarcted territories in chronic phase T2* maps. Mass spectrometry of canine myocardium showed that hemorrhagic infarctions had 10-fold higher iron content than non-hemorrhagic infarctions. In conclusion, acute IMH leads to chronic iron deposition within infarcted territories.

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Keywords

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