Meeting Banner
Abstract #0234

Casein Coated Magnetic Iron Oxide Nanoparticles for Targeted Imaging and Drug Delivery

Jing Huang1, Hyunseok Kang2, Liya Wang1, Run Lin1, Xianghong Peng2, Lily Yang3, Dong Moon Shin2, Hui Mao4

1Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States; 2Department of Haematology and Oncology, Emory University, Atlanta, GA, United States; 3Department of Surgery, Emory University, Atlanta, GA, United States; 41. Department of Radiology and Imaging Sciences, 2. Center for Systems Imaging, Emory University, Atlanta, GA, United States

Magnetic iron oxide nanoparticles have shown not only superb MRI contrast enhancement for improving diagnostic sensitivity but also unique capability of imaging guided drug delivery to facilitate the treatment. Here we report the development of a novel theranostic nanoplatform that is composed of milk protein casein coated magnetic iron oxide nanoparticles (CNIOs), near infrared dye Cy5.5, chemotherapy agent cisplatin (cis) and targeting ligand folic acid (FA). We demonstrated that Cy5.5-FAIO-cis are highly efficient in drug delivery and inhibiting tumor growth. Furthermore, the drug delivery process could be monitored by in vivo NIR/MR imaging in cancer animal models.

Abstract PDF Presentation Video

Keywords

accumulation acid administrated administration agent allow applying assay assays bearing binding blue bottom cancer capability casein cell cells characterized chem chemotherapeutics chemotherapy class coated coating collected colloidal combining composition condition confirmed confocal construct contrast coordinating cross delivery developed development diagnostic distribution dong dosage drug efficacy efficient electrophoresis encapsulated enhancing evaluate excellent exchanging exhibit experiment expressing expression facilitate form free furthermore giving grants growth guided head heating highly hydrophobic improve improved improving in vivo incubated incubating indicate infra injection intravenous investigated iron life lily link linked loaded materials mice microscopy milk mixing model models modification molecules monitored moon morphology mouse much near neck novel onto ovarian oxide particles parts physiological potential process profile protein radiology receptor reducing release report responsive sciences sensitivity shin side significantly solubility soluble stability staining stronger suggesting superb surface sustained synthetic systems tail target targeted targeting therapeutic together transverse treated treating treatment tumor tumors twice typical veil visualize vitro water