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Abstract #0230

in vivo Validation of T2-Based MR Thermometry in Adipose Tissue Layers for HIFU Near-Field Monitoring

Paul Baron1, Mario Ries1, Martijn de Greef1, Roel Deckers1, Max Khler2, Jukka Tanttu2, Chrit T.W. Moonen1, Lambertus W. Bartels1

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Philips Healthcare, Vantaa, Finland

The feasibility of using T2 mapping for monitoring the near field temperature in subcutaneous adipose tissue was investigated during a HIFU liver ablation in an in vivo porcine model. Calibrations showed that T2 changed linearly and reversible with temperature. When compared to the fiber optic probe the accuracy was better than 0.9C. During the in vivo porcine liver sonication and the subsequent cool-down period T2-thermometry allowed observing the temperature change due to near-field heating in the adipose tissue with a thermometric precision of 1.1C.

Keywords

abdominal ablation acoustic adipose allowed aqueous avoid background baron bath beam best better blue breast calibrated calibration capacity cell circuit clinical closed coefficient coefficients commonly complicated conductivity cone continuously cool cooling coronal curves cutaneous decay decrease defined dependence dependency directly distribution dose dots dual duration dynamic ensure entire every expected experiment explore exponential feasibility fiber fibroids field focused fractions future give heat heating heterogeneities homogeneous in vivo individual intensity inter intersected inversion investigated layer layers least likely linear linearity liver mapping maps mechanically medical meeting minutes model modulus monitored monitoring mono near need observing optic orange overlaid overlaying particular path peak period placed planning porcine position post power precision previously probe process prone protocol real recorded recovery reflecting removed reversibility reversible risk sample samples sciences section sedated since slice spectral stabilized strengths studies subcutaneous subsequent sufficient system target temperature thermometric thermometry tissue treatment ultrasound underlines uterine validation ventilated verify versus view volumetric water