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Abstract #0226

MRI-Guided Focused Ultrasound-Mediated Drug Delivery to Pancreatic Cancer: Safety and Efficacy

Natalya Rapoport1, Allison H. Payne2, Christopher Dillon1, Jill E. Shea3

1Bioengineering, University of Utah, Salt Lake City, UT, United States; 2Radiology Research, University of Utah, Salt Lake City, UT, United States; 3Surgery, University of Utah, Salt Lake City, UT, United States

In a preclinical animal model, tumor irradiation with focal ultrasound under the MRI guidance (MRgFUS) was applied for efficient drug delivery to pancreatic cancer using systemically injected perfluorocarbon nanodroplet-encapsulated drug (paclitaxel). MR thermometry was used to control ultrasound treatment. Focal ultrasound irradiation of the tumor triggered droplet-to-bubble transition in perfluorocarbon nanodroplets, which resulted in the local drug release into tumor tissue. Substantial regression and sometimes complete resolution of pancreatic tumors was observed. However sometimes ultrasound treatment-related complications were manifested. Pre-treatment MR images allowed revealing their cause. Efficacy and safety of the suggested treatment modality will be discussed.

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Keywords

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