Meeting Banner
Abstract #0218

Using Paired Tissue and Serum Samples to Characterize Human Lung Cancer Metabolomics with ex vivo 1H HRMAS MRS

Hailiang Huang1, Emily Decelle1, Yannick Berker1, Andreas Schuler1, 2, Isabel Dittman1, 2, Li Su3, Eugene J. Mark1, Mark J. Daly1, David C. Christiani1, 3, Leo L. Cheng1

1Massachusetts General Hospital, Boston, MA, United States; 2Charit Universittsmedizin, Berlin, Germany; 3Harvard School of Public Health, Boston, MA, United States

Despite lung cancer being the primary cause of cancer related death in both men and women in the United States, there is no early screening tool available to the general public. Due to the high costs and the radiation exposure of CT or PET, these technologies are not feasible as screening tools. Clinicians desperately need a new diagnostic tool to provide biochemical information that is essential for making early diagnoses and subsequent treatment decisions. In this study we are assessing the matched tissue and sera metabolomic profiles of lung cancer patients to discover serum metabolic markers for lung cancer.

Keywords

access added advanced agrees allowing although amount analyses analyze analyzed applying asymptomatic audience binned build cancer cartilage cell cells characterize clinical control controller cooled cross cycles dataset datasets destructively diagnosis disease distances earlier effective equal error exclude feasible feature features female fibrosis field filter fixed former fraction gender general good hazards health histological house identified identify implications in vivo inflammation intact inter laboratory lasso linear listed locking lung magic male many mark markers matched model models necrosis never numerous often operating optimal paired pathologist patient patients peak peaks predict predicted predictive preliminary probability procedure profiles prognosis program pulse quantitative radiation randomly readings reduce regularized regulated related repetition resolution rotor sample samples school screening search sections select selected selection serum sets shrinkage significantly smallest space spectra spectrometer spectroscopy spectrum spinning split stability stage stained status structures studies subsequently suspicious table target tissue tools traditional transients treatment tuned turn underway validation validations women year years