Manus J. Donahue1,
Paul Clemmons1, Ricardo Andal1, Robert Singer1,
Diane Brown1, Morgan Anderson1, Dan Claassen1,
John Connors1, Lisa Hermann1, Lori Jordan1,
Howard Kirshner1, J. Mocco1, Ryan Moore1,
Anne O'Duffy1, Derek Riebau1, Allen Sills1,
Megan Strother1
1Vanderbilt
University, Nashville, TN, United States
The purpose of this work is to develop and clinically implement a noninvasive MRI protocol for quantifying the relationship between key hemodynamic compensation mechanisms including cerebrovascular reactivity (CVR), baseline cerebral blood flow (CBF), CBF reactivity, and CBF territory dynamics in patients with cerebrovascular disease. This approach was implemented in 50 patients and results illuminated impairment not clear from structural imaging.