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Abstract #0205

Multi-Delay Multi-Parametric Arterial Spin-Labeled Perfusion MRI in Acute Ischemic Stroke Comparison with Dynamic Susceptibility Contrast Enhanced Perfusion Imaging

Danny J.J. Wang1, 2, David S. Liebeskind1, Joe X. Qiao2, Matthias Gnther3, Whitney B. Pope2, Jeffrey L. Saver1, Noriko Salamon2, Jeffry R. Alger1, 2

1Neurology, UCLA, Los Angeles, CA, United States; 2Radiology, UCLA, Los Angeles, CA, United States; 3Institute for Medical Image Computing, University of Bremen, Bremen, Germany

A novel multi-delay multi-parametric pseudo-continuous ASL (pCASL) protocol was presented. Its accuracy was evaluated by comparison with dynamic susceptibility contrast (DSC) enhanced perfusion MRI in 29 patients with acute and subacute ischemic stroke. Consistent results between multiple hemodynamic parameters derived using ASL and DSC were demonstrated.

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Keywords

account accuracy accurately acute aligned applied around arterial artery asymmetry audience background brain capability cerebral challenges coefficients complete computing concerns consecutive consistent continuous contrast control converted correction correlation correlations delay delays delineating diffusion dynamic enhanced evaluated extracted final function generated gradient implementation improved infarct institute known labeled largely latest lesion limited maps matching matrix median medical middle motion neurologists neurology noninvasive numerous offers onset opportunities pairs parametric part patients penalty perfusion pope post presence processing product prolonged protocol pseudo quantification radiology recently reduced regarding reliably remain representative residual respectively saver scanners scientists severely slices slightly spin stroke structural suggesting suppressed susceptibility taking target territories tissue transit years yielded