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Abstract #0186

Multicenter Evaluation of Dynamic Three-Dimensional Whole-Heart Myocardial Perfusion Imaging at 3.0 Tesla for the Detection of Coronary Artery Disease Defined by Fractional Flow Reserve

Robert Manka1, 2, Rolf Gebker3, Lukas Wissmann1, Roy Jogiya4, Manish Motawani5, Michael Frick6, Sebastian Reinartz6, Bernhard Schnackenburg7, Eike Nagel4, Sven Plein5, Sebastian Kozerke1

1University and ETH Zurich, Zurich, Switzerland; 2University Hospital Zurich, Zurich, Switzerland; 3German Heart Institute Berlin, Berlin, Germany; 4King's College London, London, United Kingdom; 5University of Leeds, Leeds, United Kingdom; 6University Hospital RWTH Aachen, Aachen, Germany; 7Philips Healthcare, Clinical Sciences, Berlin, Germany

Cardiac magnetic resonance imaging enables noninvasive assessment of myocardial perfusion. However, standard 2D multi-slice CMR perfusion techniques only provide limited coverage and hence prohibit computation of myocardial ischemic burden. Recently, 3D CMR perfusion has proven highly diagnostic in two single-center studies. In this preliminary assessment of our multi-center study 3D CMR perfusion imaging proved highly diagnostic for the detection of functionally significant CAD as defined by FFR.

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Keywords

accelerated accuracy analyses angiography anterior arteries artery assess assessment best blinded burden cardiac caused central classified clinical cohort college computation conclude core coronary coverage deficit defined descending detection diagnostic dimensional disease dynamic employs enrolled evaluation example excellent extensive female finding five flow fold fractional fully functionally good graded greenwood heart hence highly hospital inducible institute king kingdom lancet limited myocardial occlusion overall patent pathologic patient patients performance perfusion poor preliminary prevalence prohibit prospective proved proven providing quality quantitative recently recorded relevant remaining report representative required reserve resolution respectively rest scale sciences score segment sensitivity slice spatial specificity stress studies subtotal suspected systems visual wall whole years yields