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Abstract #0169

Susceptibility Mapping Using Regularization Enabled Harmonic Artifact Removal

Hongfu Sun1, Alan H. Wilman1

1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada

A new phase/field artifact removal method is introduced that is based on the SHARP (Sophisticated Harmonic Artifact Reduction for Phase data) method exploiting the harmonic mean value property. This new method employs Tikhonov regularization at the deconvolution stage of the mean value implementation, and is referred to as Regularization Enabled SHARP (RESHARP). RESHARP was compared to SHARP in a field-forward susceptibility simulation and in human brain experiments, demonstrating that it removes background field artifact more effectively compared to SHARP, leading to susceptibility maps with fewer artifacts and more accurate susceptibility measurement in deep grey matter structures.

Keywords

accounting accurate achieve acquisition adding agrees amplified arrows artifact artifacts background balancing better biomedical boundaries boundary brain calculations chosen complex component computing concentrated convolution covering dark datasets decomposition deep delineation denotes developed deviation deviations dimensional displays distinct distribution effective efficiency eliminate ellipsoid ellipsoids enabled engineering enhance equation error evidently expected fidelity field filtered findings five forward harmonic healthy hence human improved in vivo indicated induced induces inside intensity inter international inversion iron kernel larger least linear local magnitude majority male mapping maps measured minimal minimization model much multiplier nonnegative norm numerically original outside patterns phantom pixels posed prerequisite problem promoted quantify quantitative radius reduced referred regression regularization relaxing remaining removal remove residual resolution severe sharp simulation since singular slope smaller solution solutions solved solves spatial sphere structures subject subjects substantially suppressed susceptibilities susceptibility table term theory tissue tolerance transform true truncated truncation uniformity unique variables variation violated violating volume volunteers white year zeros