Meeting Banner
Abstract #0161

Dependence of Gradient Echo Phase Contrast on the Differential Signal Decay in Subcellular Compartments

Wei Li1, Hui Han1, Arnaud Guidon1, Chunlei Liu1, 2

1Brain Imaging & Analysis Center, Duke University, Durham, NC, United States; 2Radiology, Duke University, Durham, NC, United States

Phase images of gradient-recalled echo (GRE) have provided a new contrast for MRI. It is well known that the magnitude contrast of GRE signal changes as a function of sequence parameters including TR, TE and flip angle. The dependence of phase contrast on these parameters, however, has not been explored. In fact, phase contrast has largely been assumed in the literature to be insensitive to sequence parameters. We show that phase contrast has a profound dependence on sequence parameters that can be described by a multi-compartment model. This dependence may provide further insights of the mechanisms of susceptibility contrast.

Abstract PDF Presentation Video

Keywords

acquisition addition adjacent adult aforementioned agreement allow altered anyone assumed audience background better biological brain care certainly changing channel characterize coil coils combined comparing compartment compartments complex comprehensively consistent contain contrast contrasts contributions convenient corpus critical curve dataset decay decreases depend dependence dependent described details determine developed differential district duke equipped especially evaluated evolution experimental explain explored fact fitted fitting fixed frequency fully function future goal good gradient gray green head healthy house implication importantly in vivo insensitive inter investigation known largely least linear literature magnitude maintaining model modified necessary need needs nonlinear north optimization pool potentially preliminary previously probe profound prominent properties property proposed radiology recalled reduce reduced removed reported reproducibility scanned scanner selected selectively sharp short significantly simply software sophisticated spacing square strongly studies subject subjects suggest summarized surprisingly susceptibility table taken target tissue tissues unwrapped variables varies varying water wealth white