Meeting Banner
Abstract #0140

Magnetic Particle Imaging for Safe Angiography and Stem Cell Tracking

Emine U. Saritas1, Patrick W. Goodwill1, Justin J. Konkle1, Laura R. Croft1, Kuan Lu1, Bo Zheng1, Steven M. Conolly1, 2

1Department of Bioengineering, University of California, Berkeley, Berkeley, CA, United States; 2Department of Electrical Engineering and Computer Sciences,, University of California, Berkeley, Berkeley, CA, United States

Magnetic Particle Imaging (MPI) is a new imaging modality that re-uses FDA-approved superparamagnetic iron oxide (SPIO) nanoparticle contrast agents in a new imaging scanner (i.e., not an MRI scanner) [1-3]. The MPI method has ideal SNR, penetration, linearity and contrast, and is completely non-invasive. Moreover, compared to iodine and gadolinium, the SPIO contrast agents are much safer for patients with Chronic Kidney Disease (CKD). This work describes our state-of-the-art MPI scanners and MPIs potential for applications such as angiography and quantitative cell tracking.

Abstract PDF Presentation Video

Keywords

achieve agents already angiography applications approved approximately background believe bioengineering blood built capabilities capability cell cells chronic comparable completely computer constructed contrast croft cyan demonstrating derived describes diluted dimensional disease electrical embryonic engineering exhibits field filtered finer fold form free gadolinium geometries goodwill gradient gradients hardware helical hence human ideal improvement improvements injected injection intensities intensity introduced invasive iodine iron kidney labeled laura linearity linearly magnet magnets marked millimeter mimicking minute modality moreover mouse much nature near opposed optimized oxide particle patients penetration perfect permanent phantom phantoms photo postmortem potential produce produces projection projections quantitative reconstructed reconstruction rectangular rendered resolution resolutions rotate safe safer sample scale scales scanner scanners sciences sensitivity sites soon stem stronger system tissue tracer tracking tubing undiluted volume