Meeting Banner
Abstract #0118

Caloric Restriction Enhances Oxidative Brain Metabolism in Healthy Aging Detected by 1H[13C]MRS

Ai-Ling Lin1, 2, Daniel Coman3, Lihong Jiang3, Douglas L. Rothman3, Fahmeed Hyder3

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 3Magnetic Resonance Research Center, Yale University, New Haven, CT, United States

Caloric restriction seems to increase the lifespan in rodents. In the study, we used in vivo 1H[13C] MRS to characterize the effect of caloric restriction on rates of neuronal TCA cycle flux (VTCA,N) and total glutamatergic neurotransmission flux (Vcyc(tot)) from the glutamate and glutamine cycle in aged rats (24 months). We found that caloric restricted rats had significantly higher VTCA,N and Vcyc(tot) relative to controls, suggesting that caloric restricted rats had enhanced neuronal metabolism and that was similar to younger aged rats. This indicates that caloric restriction may delay brain age-related metabolic reduction in rodents.

Abstract PDF Presentation Video

Keywords

activity aged aging alpha alternative analyzed anesthetized animals another anti artery awake beginning best blood bodies body brain broad caloric calorie carter characterize collectively conditions consistent continuously contributing control controls cortex covered critical crucial curves cycle delay demand detected determination determine determined disorders dots edit energy enhanced enrichment examined experiment explore extend extended extracts femoral findings fits flow flux fractional fuel function future glucose glutamate haven health healthy hour hypothesized implications in vivo included infused infusions institute interestingly interplay involves isotope ketone known labeled largely lifespan ling literature localized long longevity male manipulation material mathematical measured meet memory metabolic metabolism metabolites model modeling months needed neuronal observation ones onset optimizing oxidative pathway plays preserving profound program purchased rats reduction related remain reported represent resolved respectively restriction retarding rodents role samples science significantly simultaneously since solid species spectra studied studies substrate suggesting suggests system taken term topic treated understanding variety volume weeks young younger