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Abstract #0116

Chlorine (35Cl) MRI in Humans: Cl- Alterations Do Not Correspond to Disease-Related Na+ Changes

Armin M. Nagel1, Marc-Andr Weber2, 3, Frank Lehmann-Horn4, Karin Jurkat-Rott4, Alexander Radbruch3, 5, Reiner Umathum1, Wolfhard Semmler1

1Dpt. of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 2Dpt. of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany; 3Dpt. of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 4Division of Neurophysiology, Ulm University, Ulm, Germany; 5Dpt. of Neuroradiology, University Hospital of Heidelberg, Heidelberg, Germany

Chlorine (Cl-) is the most abundant anion in the human body and is involved in many physiological processes. In this work 35Cl images of different pathologies were acquired for the first time in humans. Results were compared to 23Na MRI. 35Cl MRI revealed different signal behavior compared to 23Na MRI. Thus, 35Cl MRI can complement 23Na MRI in clinical research and might enable a better analysis of (patho-)physiological processes in the future.

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Keywords

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