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Abstract #0111

The C57BL/6 Mouse Exhibits Sporadic Congenital Portosystemic Shunts

Cristina Cudalbu1, Valrie A. McLin2, Hongxia Lei1, 3, Joao M.N. Duarte1, 4, Anne-Laure Rougemont5, Graziano Oldani6, 7, Sylvain Terraz8, Christian Toso6, Rolf Gruetter9, 10

1Laboratory for Functional and Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Dpartement de l'Enfant et de l'Adolescent, Unit de Gastroentrologie, Hpitaux Universitaires de Genve, Geneva, Switzerland; 3University of Geneva , Geneva, Switzerland; 4University of Lausanne , Lausanne, Switzerland; 5Service de Pathologie Clinique, Hpitaux Universitaires de Genve, Geneva, Switzerland; 6Transplantation Division, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland; 7University of Pavia, Pavia, Italy; 8Unit de radiologie abdominale, Service de Radiologie, Hpitaux Universitaires de Genve, Geneva, Switzerland; 9Laboratory for Functional and Metabolic Imaging, Center for Biomedical Imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 10University of Lausanne, University of Geneva, Lausanne, Geneva, Switzerland

Portosystemic shunting may be the most significant problem associated with C57BL/6 inbreeding both for its effect on gene expression in the central nervous system and its systemic repercussions.

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Keywords

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