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Abstract #0091

MRI-US Fused Targeted Prostate Biopsy Detects Clinically Significant Cancer in Active Surveillance Patients Better Than 12 Core Random Biopsy with Less Than 4 Cores

Michael Da Rosa1, 2, Laurent Milot1, 3, Linda Sugar, 34, Danny Vesprini, 35, Hans Chung, 35, Andrew Loblaw, 35, Laurence Klotz, 36, Masoom A. Haider1, 3

1Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; 2Institute of Medical Science, University of Toronto, Toronto, ON, Canada; 3Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 4Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; 5Radiation Oncology, University of Toronto, Toronto, ON, Canada; 6Division of Urology, University of Toronto, Toronto, ON, Canada

The purpose of this prospective study was to determine the ability of an MRI-US fusion biopsy system to detect clinically significant (CS) disease in active surveillance (AS) patients compared to random transrectal ultrasound (R-TRUS) guided biopsy (bx). Multiparametric MRI prospectively identified up to 4 suspicious targets in each patient. Biopsy was performed using an MRI-ultrasound navigation system (UroNav, Philips Healthcare). MRI-US fusion biopsy detected more CS cancers with fewer biopsy cores than random biopsy in AS patients. In addition, MRI in AS patients has a high negative predictive value for the presence of CS disease on subsequent biopsy.

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Keywords

ability accurate active addition address airs allow another appropriate axial better bias biopsies biopsy cancer cancers clinically coil contour core cores coronal cost costs curatively detect detected detection diagnosis disease division elect fifty final findings forty fused fusion future grade guide guided health highly identification identified identify incidence inst institute involvement labeled laboratory largest lesion lesions limit logy making median medical medicine metastatic minimize missed monitor morbidity navigation negative none onto option parametric patient patients peer permitting positive practical predictive presence prim prospectively prostate protocols radiation random rang real reduce reducing referred regularly related reported required risk scale sciences score scored selection semi significantly sitting studies sugar suite suspicious system systems target targeted targets true tumors ultrasound update zones