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Abstract #0088

Decreased Functional Connectivity After Acute Cocaine Administration: A Feasibility Study of Resting-State fMRI in Awake Non-Human Primates

Kaundinya Gopinath1, Kevin Murnane2, Leonard Howell2

1Department of Radiology & Imaging Sciences, Emory University, Atlanta, GA, United States; 2Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

Non-human primates afford distinct advantages in translational neuroimaging studies of drug addiction. To date, fcMRI studies in non-human primates have been exclusively conducted in subjects under anesthesia. In this study, resting state functional connectivity in these networks were assessed in three awake nonhuman primates, before and after acute cocaine administration. Primates exhibited a marked decrease in functional connectivity between frontal and striatal regions after acute cocaine administration, indicating impairment of neurocircuitry underlying drug addiction. Results demonstrate the feasibility of acquiring resting state functional connectivity data from awake monkeys, and provide a translational model for studying the changes induced by cocaine.

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Keywords

accordance acquiring activation acute addiction administered administration advantages alter anatomic anatomical anesthesia anesthetics animal animals another anterior approved assessed attached awake bilateral bold brain built care carried challenge chronic cocaine coil committee comprised conditions conducted confound connected connectivity consistent control coronal corrected correlation cortex cross custom datasets date decrease decreased dependent details diseased displacement distinct drug elsewhere evidence evident excessive exclusively exhibited experimenter extremity eyes feasibility female final findings frontal functional functionally gradient guide habituation healthy history human increasingly individuals induced infusion intravenous kernel laboratory locations long made maps marked medial minute model monkeys motion network networks nucleus open optimized orbital paradigm placed primate primates prior prone psychoactive quietly radiology registered removed reported resolution responsible resting restraint rhesus runs saline scanned scanner sciences seed seeds separate series served sessions setup slices smoothed spatially strong studies subject subjects supplement table taking term translational underlying underwent upon vectors vehicle volume volumes whole years