Microscopic 3D-DTI of Tumor Cell Migration, Numerical Modeling and Two- Photon Microscopic Imaging

Keywords

acquisition aims allow analyses analyzed animal applied architecture bearing berger brain brains buffered cancer cell cells cerebral chosen clinically compartment complex composed composite conditions confirmed constitute containing coronal corpus correlation cylinders days decrease density derived detected detecting developed diffusion diffusivity distribution elevated elongated encountered enlargement establish every experimentally extra extracellular fibers fixed fluorescent fractional fractions function geometry gradients green growth histograms hours immersion implantation in vivo incubated indicate individual injected interpreted intracellular invasion invasiveness laser leading letters longitudinal maps marked mice micro microscope microscopic microscopy migration mixture model modeling models monitored mosaics mouse neurosurgery noninvasive novel nucleus nude numerical occurring particularly pathologic pattern perpendicular photon pilot population powerful preliminary preserved progress proposed protein quantitative reduce release reproduce resolution respectively saline scanning section sham simulated simulations since slice slices software solution spatial stem subject suggesting tendency thesis thick thickening thicker throughout tissue tissues together trend tumor typical uniformly validate validation water white whole zoom