1Center
for Functional MRI, University of California San Diego, La Jolla, CA, United
States
A prior study has shown that caffeine reduces the amplitude of the global signal in resting-state fMRI and enhances the anti-correlation between the Default Mode Network (DMN) and Task Positive Network (TPN). In this study, we used simultaneous EEG-fMRI to investigate the neural-electrical basis of these caffeine-related effects. We found that the caffeine-induced changes in the global signal amplitude are negatively correlated with changes in vigilance derived using EEG.