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Abstract #0029

Combination of Non-Invasive Parametric MRI and Invasive Physiological Measurements: Towards a Hybrid and Integrated Approach for Investigation of Acute Kidney Injury

Jan Hentschel1, Kathleen Cantow2, Andreas Pohlmann1, Karen Arakelyan, 12, Bert Flemming2, Mechthild Ladwig2, Erdmann Seeliger2, Uwe Hoff3, Pontus B. Persson2, Thoralf Niendorf1, 4

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany; 2Institut fr Vegetative Physiologie, Charit Campus Mitte, Berlin, Germany; 3Nephrology and Intensive Care Medicine, , Charit Universittsmedizin Berlin, Campus Virchow- Klinikum, Berlin, Germany; 4Experimental and Clinical Research Center a joint cooperation between the Charit Medical Faculty, and the Max-Delbrueck Center for Molecular Medicine, Berlin, Germany

Renal medullary hypoperfusion and hypoxia play a pivotal role in acute kidney injury. Invasive but quantitative physiological methods are used for targeted probing of kidney perfusion as well as regional perfusion and oxygenation in animals in vivo. We set out to combine invasive techniques and non-invasive MRI in an integrated hybrid setup with the ultimate goal to monitor and interpret parametric MR and physiological parameters by means of standardized interventions. Our preliminary results demonstrate that simultaneous measurement of tissue pO2, flux, renal blood flow, arterial blood pressure and MRI is feasible.

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Keywords

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