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Abstract #4539

Diffusion Weighted Imaging (DWI) in the Rabbit Model of Atherosclerosis: Characterization and Quantification of Water Diffusion in Six-Month Old Aortic Plaque

Philip M. Robson1, 2, Claudia Calcagno1, 2, Sarayu Ramachandran1, 2, Venkatesh Mani1, 2, Zahi A. Fayad1, 2

1Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, United States; 2Radiology, Mount Sinai School of Medicine, New York, United States

We investigate in vivo diffusion weighted imaging in the rabbit model of atherosclerosis at 3 T using SE-DW single-shot EPI, with 12 different b-values equally spaced up to 600 s/mm2, and 16 slices in a 20-minute protocol. The average diffusion coefficient was 1.19x10-3 mm2/s and the average two-tailed span of the 90% confidence interval for the diffusion coefficient was 0.3x10-3 mm2/s, which is sufficient to distinguish normal vessel wall, lipid core, and free water. DWI is a feasible technique for quantitative characterization of atherosclerotic plaque in the NZW rabbit model in vivo and may provide important information about high-risk plaques.

Keywords

abdomen abdominal acceptable animal animals aorta aortic arise arrayed arteries assess atherosclerosis bimodal bottom channel characteristics characterization characterize circles clinical coefficient coil component components confidence consisted consistent content core determination determine development diffusion discrimination disease displayed distinguish distributed drawn drug eight encompass equally established estimation evenly facilitate fast feasible free genesis giving good gradients hemorrhage highest human identify important in vivo include induced inferior infiltration institute intermediate interval investigate knee known lead least limit lipid literature longitudinal loose macrophage male matrix measure measured media medicine model models molecular monitoring month months mount orientated others partial perpendicular physical plaque plaques plot portions precision previously product progression promise protocol pure quality quantification quantitative rabbit rabbits radiology relationship remaining renal representative resolution response risk saturated scanned school select sensitive separate shot simple slice slices slow spaced span speculate squares studies substantial sufficient supported system tailed translational treatment typical upper useful vessel wall water white whole young