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Abstract #4537

High Resolution Three Dimensional Intracranial Arterial Wall Imaging at 3T Using SNR-Optimized T1 Weighted SPACE

Lei Zhang1, 2, Qing Zhai3, Na Zhang1, 2, XiaoXin Tong3, Xin Liu1, 2, Yiu-cho Chung1, 2

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institution of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; 2Shenzhen Key Laboratory for MRI, Shenzhen, Guangdong, China; 3Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

Intracranial atherosclerosis is a major cause of ischemic stroke. T1w-SPACE can be used to image vessel wall of intracranial arteries. However, scan time, spatial coverage and contrast compete with each other in this technique. Here, Bloch equation simulation was performed to understand the relationships among these key imaging parameters. Results were verified by volunteer study. In patients, a shorter than optimal TR was need to increase anatomical coverage. Intracranial plaques were successfully identified by pre- and post-contrast T1w-SPACE. This technique may be a clinically useful tool for screening intracranial arterial disease in patients with high risk of ischemic stroke.

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Keywords

academy achieved administration anatomical anterior apparent application approved arterial arteries artery bandwidth basilar best biomedical blood carotid cause cerebral channel characterization china choice clinical clinically coil confirmed consent consents consideration contrast coverage covers dark decreases degradation density depict depicted dimensional dose eccentric efficiency enhanced enhancing ensure equation evaluated except experimental facilitates fibrous field focal function gadolinium give gives greatly guided head healthy highest identical identifying in vivo include includes informed injected inspection internal isotropic laboratory length limited limits lipid long major matched materials matrix maximized middle need needs neurology normalized numerical optimized parallel park partition partitions patient patients performance plaque plaques post priority proposed protocol recruited relatively requirements resolution risk scanned sciences segment short simulation since slab slice slices space spacing spatial stroke studies successful sufficient system technology thick thickening tissue together tortuous train trio ultrahigh understand utility validation varied various verified versus vessel vessels vista visual visualize visualized volunteer volunteers wall walls