Meeting Banner
Abstract #4527

Comparison of Fully Quantitative and Semi-Quantitative Measure of Womens Myocardial Perfusion Reserve for Detection of Microvascular Coronary Dysfunction

David Chen1, Behzad Sharif1, Afsaneh Haftbaradaran1, Melody Zaya1, Chrisandra Shufelt1, Puja Mehta1, Daniel S. Berman1, Louis EJ Thomson1, Debiao Li1, Noel Bairey Merz1

1Cedars Sinai Medical Center, Los Angeles, CA, United States

Myocardial perfusion reserve (MPR) acquired using first-pass cardiac MRI is a measure of the severity of microvascular coronary dysfunction (MCD) in subjects with signs and symptoms of ischemia but no obstructive coronary artery disease (CAD). Semi-quantitative measures (upslopes) have been used to analyze MPR data in the previous work. In this work, we propose using a fully quantitative myocardial blood flow (MBF) analysis to evaluate whether MPR is different between subjects with MCD and normal controls. MPR measured by quantitative MBF analysis provides better detection of MCD than that using semi-quantitative upslopes.

Abstract PDF Presentation Video

Keywords

abnormal additional aged analyze analyzed angiography approval artery better blood breath cardiac cedars code consent control controls coronary curves deconvolution detection disease diseased dysfunction estimation evaluate evaluation exercise explained exported finding flow flows fully heart hold improves insure intensity lung measure measured measures medical melody middle minimize myocardial national needed noel nonparametric observation obstructive pass perfusion phys population populations potentially previous propose protocol quantitative reduces related reserve rest risk segmentation segments semi semiquantitative sensitive severity sided signs sponsored standardized stress student studies subjects summarized symptoms syndrome system table tissues trend underwent upslope validation variations vascular whether wise women written yielded