Meeting Banner
Abstract #4514

Changes of Myocardial Lipid Content and Left Ventricular Function in the Course of Acute Hypoglycemia and Inhibition of Lipolysis.

Martin Krssk1, 2, Yvonne Winnhofer1, Peter Wolf1, Drazenka Jankovic1, Sabina Baumgartner-Parzer1, Rodrig Marculescu3, Michael Wolzt4, Siegfried Trattnig2, Anton Luger1, Michael Krebs1

1Division of Endocrinology and Metabolism, Department of Intrenal Medicine III, Medical University of Vienna, Wien, Austria; 2Centre of Excellence High Field MR, Department of Radiology, Medical University of Vienna, Wien, Austria; 3Department of Laboratory Diagnostics, Medical University of Vienna, Wien, Austria; 4Department of Clinical Pharmacology, Medical University of Vienna, Wien, Austria

Proton MRS and MRI were used to follow the myocardial lipid content (MYCL) and left ventricular ejection fraction (LVEF) in the course of acute hypoglycemia and 24h follow up in young healthy male volunteers (n=8). Lipolysis was alternatively inhibited to distinguish the effects of hypoglycemia and counter-regulation induced lipolysis. Acute hypoglycemia did not reduce the LVEF and MYCL, but MYCL decreased in 24h follow up measurement. Inhibition of adipose tissue lipolysis w/o insulin action was accompanied by decrease of MYCL and LVEF. We conclude that MYCL stores play a major role for the maintenance of myocardial function.

Abstract PDF Presentation Video

Keywords

according accumulation acids acquisition action acute adipose adjustment aimed alternative another apex applied assessed automatic avoiding axes beat body breath cardiac cardiovascular chamber clinical coils compartment complications content control counter course days decrease described detected detection development diabetes diastolic distribution double ejection elevated emerged episode episodes examination excellence experiment failure fast field fraction frequency function global glucose healthy heart hence hold hormones hours hypoglycemia hypoglycemic individual induced induction inhibition inhibitor insulin intensity leads lipid liver major male mapping mass mater measured mechanism medical medicine metabolism midway minimal minutes myocardial myocardium nature next noted package patients peter phys placebo plasma plays plus pool positioned press processed prospective published radiology recalled recently reduction regulation regulatory relates repeated repeatedly reported revealed separate septum session shim shimming short significantly software spectroscopy steady stores stroke substantial substrate sufficient suggested suppressed suppression system systolic tight timing tissue transient trials true twenty underwent ventricular volume volunteers water young