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Abstract #4496

Sheet Tractography Provides a Multi-Dimensional Representation of Architecture in Normal and Infarcted Hearts

Choukri Mekkaoui1, Marcel Parolin Jackowski2, Timothy G. Reese3, David E. Sosnovik3

1Harvard Medical School - Massachusetts General Hospital - Athinoula A Martinos center for Biomedical, Boston, MA, United States; 2University of So Paulo, So Paulo, Brazil; 3Harvard Medical School - Massachusetts General Hospital - Athinoula A Martinos center for Biomedical, Charlestown, MA, United States

Diffusion Tensor MRI (DTI) has shown that the orientation of the secondary and tertiary eigenvectors in the diffusion tensor correspond to the orientation of the myolaminar sheets in the heart. Myofiber tractography methods, however, have traditionally relied solely on the primary eigenvector to determine fiber trajectory. Here, we extend tractography in the heart by using the secondary and tertiary eigenvectors to reconstruct multi-dimensional tractographic sheets. We show that the rotation of these sheets defined by the torsion angle, is reduced in remodeled hearts.

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Keywords

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