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Abstract #4456

Quantification of Aortic Pulse Wave Velocity in Preterm Infants Using 4D Phase Contrast MRI

Kathryn M. Broadhouse1, 2, Anthony N. Price1, 2, Giuliana Durighel1, Anna E. Finnemore1, 2, David J. Cox1, 2, A. David Edwards1, 2, Joseph V. Hajnal1, 2, Alan M. Groves1, 2

1Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, London, United Kingdom; 2The Centre for the Developing Brain, Imaging Sciences & Biomedical Engineering Division, King's College, London, United Kingdom

A significant increase in pulse wave velocity (PWV) has been found in paediatric subjects born prematurely at low birth weight when studied at ~8yrs and may explain the increase in cardiac disease in this population. However PWV data does not extend back to preterm infants. The aim of this study was to assess the feasibility of measuring aortic PWV in preterm and term infants using 4D PC MRI, in order to establish a normative range in this population and facilitate comparison with adult values. PWV velocity in neonates was found to be at the lower end of reported adult ranges.

Keywords

accurate accurately acquisition adult adults anesthesia aorta aortic arch assess audience available background biomedical blood body born brain calibrated capable cardiac cardiologists cardiovascular channel child circulation circulatory clinical coil college combined commercially complex compliance confirms consecutive contrast coordinates corrected coverage define defined delay delays descending determine determined determining developing differs disease diseased distance division documented encoding engineering establish explain extremity facilitate feasibility flow front full global gradient grams graph groves healthy human immature imperial infant infants initial interpolation inverse isotropic journal king kingdom least length location locations lumen marker measure measured mechanical median medicine merchant minutes monitoring near neonatal neonates normative paediatrics physiology plotted poorly population prematurely previously price propagating protection providing pulse quantification quantified receive recent reported resolution routine scaled scanned scanner sciences sedation significantly slope software spatial still studied studies subjects subsequent sufficient system systolic taken target temporal term tool upslope upstroke valve velocity vessel vessels volume wave whilst