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Abstract #4438

Reproducibility of Flow Measurements in Serial Studies of Patients with Untreated Aneurysms

Gabriel Acevedo-Bolton1, Andrew Lee1, Vitaliy L. Rayz1, Alastair Martin1, David A. Saloner2

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 2Radiology and Biomedical Imaging, VAMC/UCSF, San Francisco, CA, United States

MR velocimetry reproducibility was mesured in a cohort of 88 subjects with untreated aneurysms that were evaluated repeatedly over periods of time as long as 7 years. Reproducibility was also measured in exact replicas of the complex geometries of a subset of these subjects. Good agreement was found between experimental and computational flow measurements. In vivo studies were found to be reproducible with an error of measurement of 10%.

Keywords

accessible accuracy achieved acquisition addition adjacent aneurysm aneurysms annually apart approved arteries artery assess assessed assessment basilar biomedical blue boundary calculations capability cardiac carotid circulation cohort complex computational conditions conducted consistent constructed contrast coronal cycle definition determination determined disease disks distribution dynamics error establish establishing evaluate evaluated evaluating even evolution exact excellent experimental experimentally extensive feeding field fields flow fluctuating fluctuations fluid fusiform general geometries geometry green highly immediately important improved in vivo indicate internal interval intervals invasive larger lengthy limitation made many martin matched measured methodologies modalities model models months much noise particular particularly patient patients peak performance period permit physiological postulated powerful practical predict predicted protocol purple questionable radiology reduce reduced remain remains repeatedly replica report representative reproducibility reproducible resolution selected sensitivity serial session settings shear simplified smaller something straight stress studies subjects subsequent subset substantial transverse tubes underestimation unique untreated variability variation varying vascular velocity vessels vitro volume year years