Meeting Banner
Abstract #4231

A Free Breathing, Retrospectively Gated, Saturation Transfer Encoded Steady State Cardiac Cine Method for Preclinical Chemical Exchange Saturation Transfer Imaging in the Heart

Moriel Vandsburger1, Avigdor Leftin1, Senzeni Mpofu1, Michal Neeman1

1Weizmann Institute of Science, Rehovot, None, Israel

Chemical exchange saturation transfer (CEST) imaging is emerging as a powerful MRI technique for selective visualization of a variety of targeted contrast agents and synthetic reporter genes. CEST imaging has been applied primarily to stationary organs or tumors, and never to the heart because of cardiac and respiratory motion. We developed a free breathing, retrospectively gated, CEST-encoded steady state gradient echo cardiac cine imaging sequence for the purpose of pre-clinical cardiac CEST imaging.

Keywords

ability acquisition advanced agents artifact asymmetric award bandwidth bias body brain breathing cancer cardiac chemical cine circulating clean clinical coil combined commission complete correction council cycle cylindrical delay described developed diagram diastolic direct duration efficiency either element encoded encodes encoding exchange excitation executed fellowship frames free frequencies frequency full gated gating genes gradient grant half heart imago included incrementing initial institute integrated intensity inter kidney largely limit limited longitudinal macromolecules magnetization maintained male matrix measured measuring minimal models module modules motion myocardial myocardium never none normalize normalizing obviate offset offsets organs overwhelmingly plot powerful preparation prior profile project pulse pulses rapid readout receiver referencing regional regionally remove repetitions reporter representative residual resonant respiratory retrospectively revealed reveals sample saturation scanner schemes science selective sensitivity series several short slices spatial spectra spectrum spin stationary steady studies subsequent subsequently surface synthetic system targeted temperature throughout train transfer uniform unnecessary variety volume water week wise