Meeting Banner
Abstract #4200

Value of High Field Dependent Transverse Relaxation Increase for Increasing Iron Specificity in Human Brain

Md Nasir Uddin1, R. Marc Lebel1, Alan H. Wilman1

1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada

Transverse relaxometry at multiple field strengths may provide increased iron specificity using field dependent relaxation increase (FDRI). We compared high field (4.7 T) transverse relaxometry to single and multislice FDRI using 1. 5 T and 4.7 T. Results for iron-rich subcortical grey matter demonstrate the value of high field measurement, with only slight improvement using FDRI.

Keywords

achieved acquisition adiabatic affect affected alone although appears applied biomedical brain capturing combined comes compensation component concentration confound confounded considering consistent contains content controls corrects correlate correlated correlation correlations cortical delay dependent deposition determined dimensional disease disorders dual echoes eliminate engineering equations even example exchange excitation extended fact female field fitting five fraction frontal gray greater healthy heme highest human in vivo incidental increasing indicate indicating induced informed inherent inhomogeneity investigate iron keeping largely length limitation limits linear linearly macromolecular magnetization make male maps marker mater matrix maximized measured minimal mode much multicomponent needing nine nucleus overcome pixel plotted pools preclude presence previous price pulses reduced reduction reflect refocusing regression relationship relying required resonant rich sclerosis selective sensitivity slice slices spacing specificity spin stay stimulated strength strengths strong strongly structures studies subjects subtracting sufficient suggested surrogate system table territories tissues train transfer transverse traverse true twice valuable versus volunteer water weaker white years