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Abstract #4079

A Novel Approach for Hepatic Viscoelastic Characterization Using Magnetization-Tagged MRI and Single-Degree-Of-Freedom (SDOF) Viscoelastic Model

Sohae Chung1, Leon Axel1

1Radiology Department, Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY, United States

Magnetization-tagged MRI was used to measure the cardiac-induced motion and deformation in the liver for assessing liver stiffness. In this study, we extended the previously used simple elastography estimation of liver stiffness, which have primarily considered the elasticity alone, to include viscoelastic properties, by looking at the time behavior of the cardiac-induced motion. A single degree-of-freedom (SDOF) viscoelastic model was applied in healthy subjects and patients with cirrhosis. The results showed statistically significant differences in the "stiffness" and the "damping" between healthy and cirrhosis livers, and it may provide an additional novel means for tissue characterization.

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Keywords

additional alone applied approaches assess assessment bank behavior biomedical breath cardiac characterization cirrhosis considered cycle damping deformation degree described differently disease displacement elasticity estimation excitation extended feature fibrosis filter fitting force freedom future greatest harmonic healthy hepatic holding important include induced known least liver livers loaded local looking made magnetization marker measure mechanical medical model motion noninvasive nonlinear normalized novel occurred patient patients peak phantoms plots presence previous previously primarily prognostic progressive properties radiology representative respectively respond scanned serve simple square statistically stiffness still strong studies subject subjects system systole tagged tissue treatable trio validation viscoelastic volunteers years