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Abstract #4011

Measurement of Brain Metabolites Using a Lactate Enhanced Detection Chemical Shift Imaging (LED-CSI) Pulse Sequence

Xian-Feng Shi1, 2, Andrew Paul Prescot, 23, Young-Hoon Sung1, 2, Douglas Kondo1, 2, Seong-Eun Kim3, Eun-Kee Jeong, 23, Perry F. Renshaw1, 2

1Department of Psychiatry, University of Utah, Salt Lake City, UT, United States; 2The Brain Institute, University of Utah, Salt Lake City, UT, United States; 3Department of Radiology, University of Utah, Salt Lake City, UT, United States

Numerous reports indicate that the elevated brain lactate levels are present in patients with psychiatric disorders. One hypothesis is that oxidative metabolism using glucose is dysfunctional. Therefore, glycolytic conversion of pyruvate to lactate acid is activated to compensate for an insufficient energy supply in order to maintain normal brain activity. The challenge associated with lactate detection at TE=135 ms is signal nulling due to the four compartment artifact. A lactate enhanced detection chemical shift imaging pulse sequence (LED-CSI) is developed by applying a nonselective RF pulse to minimize the four compartment artifact and enhance lactate signal detection.

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Keywords

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