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Abstract #4001

Heterogeneity of Phosphorus-Containing Compounds Across Gray and White Matter in the Human Brain

Jonathan A. Dudley1, 2, James C. Eliassen1, 2, Melissa P. DelBello2, Stephen M. Strakowski, 12, Caleb M. Adler, 12, Wade Weber2, Martine Lamy1, Elizabeth M. Fugate1, Wen-Jang Chu1, 2, Jing-Huei Lee1, 2

1Center for Imaging Research, University of Cincinnati, Cincinnati, OH, United States; 2Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, United States

Concentrations of phosphorus-containing metabolites were estimated in pure gray and white matter tissue by performing tissue regression analysis on combined anatomic and phosphorus MRSI data from thirty-six healthy subjects. Significant heterogeneity was observed for all metabolites as well as intracellular pH. The results indicate substantial differences in the brain bioenergetics and phospholipid metabolism between these tissue types which may partially elucidate various results from previous studies of various pathologies such as schizophrenia and Alzheimer's disease.

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Keywords

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