Meeting Banner
Abstract #3995

Occipital Lobe Metabolic Aberrations in Alcohol Dependents: An in-vivo Proton Magnetic Resonance Spectroscopy Study

Deepika Bagga1, Namita Singh1, Shilpi Modi1, Pawan Kumar1, Debajyoti Bhattacharya2, Mohan Lal Garg3, subash khushu1

1NMR Research Centre, INMAS, New Delhi, India; 2Department of psychiatry, Base Hospital, New Delhi, India; 3Department of Biophysics, Panjab University, chandigarh, India

Proton in vivo Magnetic Resonance Spectroscopy (MRS) study on occipital lobe was performed on alcohol dependents and healthy controls to look for the metabolic aberrations underlying the visual information processing deficits observed in alcohol dependents as assessed by PGIBBD(PGI-Battery of Brain Dysfunction).A significant reduction in NAA/Cr and Glx/Cr ratios and a significant increase in Cho/Cr and Ins/Cr ratios was observed which could possibly account for impaired visual skills (as indicated by higher dysfunction rating scores) in alcohol dependents.

Keywords

aberrations abilities abstained abstinent abuse acoustic activation adaptation addiction additional alcohol alcoholic alcoholics alcoholism alterations altered assessed attributed audience basic battery besides better biology biophysics body brain carried cell channel choline chronic cognitive coil combined compounds compromise concentrations containing contribute controls corporation deficit deficits dependence dependent dependents detoxified drug dysfunction earlier education elevations examination explore extensive field function functions glutamate guided handbook head healthy hospital impaired in vivo indicate insight investigate journal lobe localized look loss matched material measured membrane mental metabolic metabolism metabolite might model national neuronal occipital osmotic paradigm patients perception period perturbation plus probably processing proliferation proton psychiatry psychological radiology rating recently recognition reduced reductions reflect relationship remission reported represent researchers resolution response responsible retention rotation scale score scores sensitivity sensory shrinkage significantly spatial spectra spectroscopy status stimulation strength studies subjects subtest susceptibility system table target tasks various version visual week whereas whole