Meeting Banner
Abstract #3993

in vivo and Longitudinal Assessment of Brain Metabolism in Hepatic Encephalopathy Using 1H MRS

Cristina Cudalbu1, Valrie A. McLin2, Olivier Braissant3, Rolf Gruetter4, 5

1Laboratory for Functional and Metabolic Imaging (LIFMET), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Vaud, Switzerland; 2Dpartement de l'Enfant et de l'Adolescent, Unit de Gastroentrologie, Hpatologie et Nutrition, Hpitaux Universitaires de Genve (HUG), Geneva, Switzerland; 3Service of Biomedicine, Lausanne University Hospital, Lausanne, Vaud, Switzerland; 4Laboratory for Functional and Metabolic Imaging (LIFMET), Center for Biomedical Imaging (CIBM), cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland; 5University of Lausanne, University of Geneva, Lausanne, Geneva, Switzerland

We characterized for the first time the in vivo and longitudinal progression of HE in a model of CLD using 1H MRS and histology and consequently we were able to monitor changes in the brain osmolytes, neurotransmitters, antioxidants and cell swelling.

Abstract PDF Presentation Video

Keywords

accepted acidic acids acquisition activity acute adjusted agreement allowing allows already alterations altered amino ammonia among antioxidants apparent array arrows assessed assessment bile biomedical bottom brain built cell cerebral channels characterized chronic coma compensate compensated compensatory complex complication concentrations considered context continuous control death decrease decreased deficit details development disease disturbances double duct edema eight encephalopathy energy especially even excellent exhibited expression field foundations functional glutamate hepatic histological histology home humans impairment in vivo induction involved involvement knowledge leading ligated ligation liver localize longitudinal longitudinally mandatory marker measured mechanisms mental metabolic metabolism metabolite metabolites minimal model motor neurological neurotransmitter neurotransmitters notable noticed onset osmotic oxidative pathogenesis pathogenic pathways previous previously principal prior profile progression promising protein radical rats reaching reported represent respectively scanned scientific serious service short simple something sometimes special spectra spectroscopy started status still stress swelled swelling symptom system target thick though transduction transporters trend typical ultra unique unit week weeks