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Abstract #3958

Partial Volume SLIM for Separating Water and Lipid Compartmental Signals in Breast MRS

Patrick J. Bolan1, Gregory J. Metzger1, Steen Moeller1, Michael Garwood1

1Radiology, CMRR, University of Minnesota, Minneapolis, MN, United States

This work explores the feasibly of using reconstructions based on Spectral Localization by Imaging (SLIM) to separate the spectral signals from the aqueous and lipid compartments in the breast. Fat fraction and B0 maps derived from high-resolution water-fat imaging are used to create a geometric model of the breast. A conventional CSI spectral data set is then reconstructed using SLIM and the geometric model to create discrete spectra for the water and lipid compartments. The feasibility of this approach is demonstrated through simulation and in vivo measurements.

Keywords

accurate acquiring acquisition acquisitions addressed adjustments allows appropriate aqueous array background best bias breast cancer challenging chemical choline clinically coil combined comparable compartment compartmental compartments condition conditions consistently consisting contains converted coronal correctable corrected correction correctly dataset density discrete distribution divide domain domains encoded encodes even exact expertise extensions extraction feasibility female field form fraction fractional frequency full function future generally generated geometric geometry gradient homogeneous improved in vivo include incorporate incorporated inverted known leads lipid localization make mapping maps matrix measured metabolic minutes model modeled noise object oblique optimal optimized overlap partial patient peak perfect perfectly plan planning plus potential primary produce produces pure quality radiology receive reconstruct reconstructed reconstruction reconstructions reconstructs regularization requires resolution sampling scanned selected separated separating shim simulated simulation since slice slim sloop solve space spatial spatially spectra spectral spectrally spectroscopy spectrum strategy subject synthesized synthetic taken though toolbox trans transform unilateral valuable volume volunteers waits water widths