Meeting Banner
Abstract #3954

Multi-Resonance 3D Spin-Echo EPI With Chemical Separation For Fast Hyperpolarized 13C MRI

Peter J. Shin1, Peder E.Z. Larson1, Martin Uecker2, Michael Lustig2, Daniel B. Vigneron1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 2Electrical Engineering and Computer Science, UC Berkeley, Berkeley, CA, United States

In hyperpolarized 13C experiments, data acquisition window is limited by the rapid metabolism and T1 relaxation of the hyperpolarized signal. This necessitates fast imaging schemes such as echo planar imaging (EPI). In this project, we developed a fast 3D EPI sequence for rapid 13C data acquisition and an accompanying multi-channel chemical separation method based on joint estimation of coil sensitivities and images of different molecules.

Abstract PDF Presentation Video

Keywords

accompanying acquisition addition alanine anatomical animal application approaches artifacts audience axial band better biomedical blipped body bottom channel channels chemical chopping clam coil coils collect collected computer condition conditioning constraint containing contributions coverage custom dedicated delay delivery denotes depending design designed details developed done electrical enable encoding engineering ensure ensures entire estimation excitation excite exciting experiment fast field final frequencies frequency fundamentally gradient hence hydrate in vivo injected introduce inverse inversion iterative joint jointly just kidneys lactate limited load loader magnetization magnitude martin matrix metabolic metabolism metabolites modulation molecular necessitates negating note observe optimal originating paddle perturbing peter placed polarization positioned preliminary problem products progressively project proper properly pulse pulses radiology rapid readout receive reconstruction reed researchers resolution resonant sample scheme schemes science sensitivities separate separates separating separation setup shin simultaneous solve solved spatial species spin spins started step structural substrate suppressed tailored target together transform transmitter urea utilization vary view volumetric window