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Abstract #3949

A Device for Accurate and Automated Injection of Hyperpolarization Substrate with Minimal Dead Time and Arbitrary Volumes

Steven Reynolds1, Adriana Bucur1, Michael Port2, Tooba Alizadeh3, Samira Kazan3, Gillian M. Tozer3, Martyn Paley1

1Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; 2Biological Services Unit, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; 3Department of Oncology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Modelling of hyperpolarized pyruvate to lactate conversion can be improved upon with consistent and reliable injections using an automated system. We have improved upon our previously designed injector by using a completely MR compatible direct drive peristaltic pump with a stepper motor and microcontroller. The new injector allows faster injections, no syringe filling, and arbitrary injection volumes. We show excellent correlation between demand and delivered volumes in the range 0.100-10.00ml and faster delivery of hyperpolarized pyruvate into a test phantom.

Keywords

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