Investigation of Substrate Dose on Rat Cardiac Metabolism in Vivo Using MRS of Hyperpolarized [2-13C]pyruvate

Keywords

ability absorption abundance account acid acids activity acutely addition additional alanine allows animal assessment bicarbonate body bolus built cardiac cardiovascular coil concentration concentrations contrast converts courses custom cycle decay decrease demand detected dirk diseases dose doses doublet downstream dynamic either elevated every exchange fast fate fatty flux free generated glutamate grants greater hard healthy heart illustrates immediately impact importance improved in vivo incorporation induction infused injected injection injections instruments international investigation known label labeling lactate male mayer measure measured metabolic metabolism metabolite mode myocardial natural normalized observe overlapping oxford oxidation oxygen paired park pathways peak permit perturbations placed post probe probing pulse rats receive received reflect reflected reflecting releasing representative response scanner similarly solution spectra spectral starting steps studies substantial substrate subtracted summing supine surface track transmit upfield whereas width workload zoomed