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Abstract #3893

Super-Relaxive Gd Nanoparticle

Ananth Annapragada1, Eric Tanifum1, Ketan Ghaghada1, Divya Sabapathy1

1Pediatric Radiology, Texas Childrens Hospital, Houston, TX, United States

Novel presentation of Gd atoms on nanoparticles were tested, to identify the mechanism of hyperrelaxivity of nanoparticle presented Gd. A new lipid construct with dramatically higher relaxivity is described.

Keywords

agent agents atoms audience bilayer chelate conjugated conjugates consistent construct constructs containing contrast derivatives development directly fabricated facilitate field flexible formulations function gadolinium glycol highly hospital identify inverse investigated mechanism molecular novel optimize pediatric polyethylene polymer presentation radiology relationship sensitive significantly strength super surface synthesized target targets tether tethered theory traditional vitro