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Abstract #3872

Optimal Field Strength for Molecular MR Imaging : Detection of Targeted Gd-Based Contrast Agents on a Living Cell Monolayer

Nicolas Gargam1, Marie Poirier-Quinot1, Jean-Christophe Ginefri2, Jean-Sebastien Raynaud3, Philippe Robert3, Luc Darrasse1

1Univ Paris Sud, CNRS, UMR 8081, IR4M, Orsay, France; 2Univ Paris-Sud, Orsay, France; 3Guerbet, Research, Roissy CDG cedex, France

The variation of relaxivity of macromolecular contrast agent as a field function, and the contrast to noise then induced, had already been studied in vitro, but had not yet been highlighted in live cells. The dynamic uptake of a Gd-based nanoemulsion by a cell monolayer is investigated here at 2 field strenghts, 4.7 T to 2.35 T, leading to a signal enhancement of 2.7. That results tends to be in line with in vitro theoretical study showing the efficiency of a paramagnetic nanoemulsion as a field function, raising the question of the optimal field strenght for molecular MR Imaging.

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Keywords

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