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Abstract #3594

Prominent Nodal Role of Amygdala and Nucleus Accumbens and Altered Prefrontal Strength in Functional Connectivity in Pediatric Bipolar Disorder

Minjie Wu1, Alexander Kmicikewycz1, Shaolin Yang1, Lisa Lu1, 2, Donatello Arienzo1, Mani Pavuluri1

1Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Psychology, Roosevelt University , Chicago, IL, United States

Applying graph theory analyses to resting state brain functional data, the present study aims to characterize the system-level changes in brain organization at rest in PBD. Significant increased betweenness centrality in PBD is observed in left amygdala, nucleus accumbens, precuneus, and right temporal pole. PBD also showed significant decreased connectivity degree in left medial OFC, and increased connectivity degree in right DLPFC. The pattern of increased thoroughfare via subcortical nodes of amygdala and nucleus accumbens and altered connectivity strength of DLPFC and OFC offer strong support of how affective and reward circuits are potentially interlinked and impaired in PBD.

Keywords

affect affective altered analyses approved architecture around assent axial betweenness beyond bipolar black blue board bold brain bravo care centrality characterize circuits clustering coil combined connectivity consistently construct controls correction correlation cost cross cyclical decreased deficits degree density disorder efficiency electric examined extract favor filtered fluid forty frames frequency frontal function functional general global graph graphs head health healthy hundred illness impaired individual informed institutional intensity interlinked lead least load local loss mapped matched materials matrix meanwhile medial medium modulation motion needs network networks nodal node nodes nucleus nuisance offer overall parent participants participated passing paths patients pattern pediatric placed pole poor potentially preprocessed preserved processing prominent pronounced psychiatry psychology reached reflect reflects regional registration regression regulation related removed represents rest resting review reward rewards rich role roles scanned slice slices strength strong strongest subject subjects subsequently suggests support system task terms theoretic theoretical thoroughfare threshold tolerance vertical white world years