Meeting Banner
Abstract #3590

Altered White Matter Myelination in Chronic Schizophrenia

Mariana Lazar1, Dolores Malaspina2, Laura Miles1, Ali-mohammad Golestani1, Nicole Peccerelli1

1Department of Radiology, New York University School of Medicine, New York, NY, United States; 2Department of Psychiatry, New York University School of Medicine, New York, NY, United States

DTI literature widely reports reduced fractional anisotropy (FA) in schizophrenia. However, the underlying white matter pathophysiology remains unclear as differences in FA can stem from a variety of causes including differences in myelination and fiber density and geometry. In this study we employed Diffusion Kurtosis Imaging in conjunction with a newly proposed two-compartment white matter diffusion model to evaluate differences in axonal density and myelination in chronic schizophrenia. Our results suggest atypical myelination as a pervasive pathophysiological feature of the disorder. Fiber density does not appear to be significantly affected in this population.

Keywords

acceleration additional affected agents altered appear appears approaches around attempts atypical auditory axial axis body bottom brain capsule chronic clinical coil compartment compartments components consistent control corona corpus corrected coverage created criteria decreased density development diagnosis diagnostic diffusion diffusivity dimensional direct directly disorders distortions distributed edition eighteen element evidence examine examined expert expression extended extra feature fiber field findings fraction fractional free future gene genes goal gradient handed handedness histological hypothesis implications include included indirect inhomogeneities instrumental integrity internal interview intra investigate knowledge kurtosis laura literature made male maps match measure measures medical medicine metrics minutes model monitoring motion newly optic package parametric parental participants patient patients pervasive population potentially primarily proposed psychiatry radial radiology reduced remains reports schizophrenia school selecting sets significantly slice slices socio software solutions spatial statistic status stem strongly structured studies subject subjects suggest suggested superior support target targeted tort treatment treatments variables variety water white years