Meeting Banner
Abstract #3569

Changes in Upper Alpha EEG Power Predict Performance in Real-Time fMRI Neurofeedback Training of Amygdala

Vadim Zotev1, Han Yuan1, Masaya Misaki1, Raquel Phillips1, Kymberly D. Young1, Jerzy Bodurka1, 2

1Laureate Institute for Brain Research, Tulsa, OK, United States; 2College of Engineering, University of Oklahoma, Tulsa, OK, United States

We have conducted the first study in which EEG recordings were performed simultaneously with real-time fMRI neurofeedback (rtfMRI-nf) to explore electrophysiological correlates of rtfMRI-nf training. Eleven MDD patients learned to self-regulate their left amygdala activation using rtfMRI-nf during a positive emotion induction task based on retrieval of happy autobiographical memories. We observed significant task-dependent increases in relative upper alpha EEG power that inversely correlated with fMRI activation levels of the amygdala. Our results suggest that increased cognitive effort, reflected by the changes in upper alpha EEG power, is associated with reduced efficiency of emotional self-regulation during rtfMRI-nf training.

Keywords

achieve activation alpha anti approaches array artifacts attention attentional audience aversive axial band block blocks blue brain channel channels cognitive coil college computed concurrently condition conditions consisted consistent correlate correlation correlations count dedicated defined determined development discovery disorder disorders effort emotional emotions employing essential everybody except excluded exhibit exhibits experimental fact feel females fink frequency gradient half happy head height included increasing indicate individual individually induction instructed interval known laureate learning long major many matrix mechanisms memories memory mood negative networks neuropsychiatric normalized novel parietal part participant particularly patients peak performance positive posterior power practice preceding predict presumably processing products promising proper protocol real reappraisal receive recordings reduce reduction reflect reflecting regulation removed requires researchers residual resolution responders rest runs scores screen self sense setup seven shot slice slices slopes software stimuli strategies stronger subject subplot subtraction suggest system target task therapeutic together training treatment unable upper utilizing variations wavelet young