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Abstract #3561

Neuroimaging Biomarkers of Mild Traumatic Brain Injury (MTBI) and Its Recovery: A Preliminary Study in Acute Setting

Jie Yang1, Zhifeng Kou1,2, Robert Dean Welch3, Randall Benson4, Ramtilak Gattu2, Valerie Mika3, Ewart Mark Haacke1

1Radiology, Wayne State University School of Medicine, Detroit, MI, United States; 2Biomedical Engineering, Wayne State University, Detroit, MI, United States; 3Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, United States; 4Center for Nerologic Studies, Novi, MI, United States

Using SWI and resting-state fcMRI methods, this study aims to provide neuroimaging biomarkers that may reveal neurovascular deficits and changes in function connectivity of patients post traumatic brain injury at the acute stage. Subtle medullary vein damage seen by SWI and disrupted resting-state networks indicated by fcMRI, together with the changes in these MRI indices over time will be imaging biomarkers complimentary to routine clinical evaluation of mTBI patients.

Keywords

acute advanced anatomical application approximate arrows assessment assistant association atlas attention basic brain carried clinical cognitive complimentary concussion connectivity consistent conspicuous control controls coordinates correlation cross damage dean default deficits defined develop differentiate disruption distinctive door edition emergency enough enrolled evaluate evaluated evaluation facilitate females field findings frontal function functional functions generated head healthy hospital hours identify indicate indicated inferior injury involved lack largely lesions lobule lost majority making management mapped mapping maps mark matched matrix measures medicine memory middle mild minute mode month months network neural neurology opens outcome parametric parietal patient patients perfusion physicians poised post predict preliminary process processing radiology received receiving recovery related reported representative resolution resting reveal routine sample scale scanner school score seed selected session setting significantly slices speed stage standardized started structure studies subtle superior susceptibility susceptible symptomatic symptoms system taken temporal together tomography trauma traumatic understanding vein veins view visit whether years yellow