Meeting Banner
Abstract #3389

Combination of MR Spectroscopic and Diffusion Weighted Imaging of the Prostate for the Prediction of Tumor Aggressiveness

Josephin Otto1, Gregor Thrmer1, Christian Schrder1, Nikita Garnov1, Lars-Christian Horn2, Minh Hoang Do3, Jens-Uwe Stolzenburg3, Michael Moche1, Thomas Kahn1, Harald Busse1

1Diagnostic and Interventional Radiology Department, Leipzig University Hospital, Leipzig, Saxony, Germany; 2Institute of Pathology, University of Leipzig, Leipzig, Saxony, Germany; 3Department of Urology, Leipzig University Hospital, Leipzig, Saxony, Germany

Active surveillance is regarded as an option to reduce overtreatment in patients with organ-confined low-risk prostate cancer. Transrectal ultrasound-guided biopsy is currently the only method for disease monitoring but has some disadvantages due to its invasive nature and underestimation of tumor dedifferentiation. Multiparametric MRI, on the other hand, can provide quantitative parameters of tissue function that may help to assess tumor aggressiveness. This work evaluates the predictive value of combined DWI and MR spectroscopic parameters to discriminate indolent from aggressive carcinoma.

Keywords

accuracies achieved acknowledged active aggressive aggressiveness annual apparent assess assessment assigned best biopsy blinded blue calculating cancer characteristic chemical choline citrate classified clinical coefficient combination combined combining component confined confirmed considered correctly correlated correlation covering criteria curves defined determine determined diagnostic diagrams differentiate differentiating diffusion discriminatory disease distinguish edge error established evaluated example experienced function functional gold grade grant greatly guidance guided healthy highest highlighted highly horn hospital identified included increasingly indolent institute intermediate lesions localization location marked matched material materials measured mirror monitoring morphologic morphological mount nearest nine noninvasive normalized operating option organ pathologist pathology patient patients plot power prediction preoperative press promising prospectively prostate protocol qualitative radiologist radiology reader receiver reduce resolution respectively reviewed role sampling score section sections sensitive slice slices spectroscopic spectrum step substantial suited support surveillance thirty threshold thresholds transverse trio tumor tumors ultrasound undergoing undergone urology volume whole yellow