Meeting Banner
Abstract #3365

Age Correlation of Background Breast Tissue Enhancement Measured from the Entire Segmented Fibroglandular Tissue and the Hot-Spot in DCE-MRI

Xiaoyong Wang1, Jeon-Hor Chen2, Christine Hsu2, Shadfar Bahri1, Hon J. Yu1, Peter T. Fwu1, Muqing Lin1, Min-Ying Su1

1Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2Center for Functional Onco-Imaging, University of California Irvine, Irvine, CA, United States

This work analyzed the background breast tissue enhancement in the contralateral normal breast of patients diagnosed with breast cancer. A computer program is used to segment the entire fibroglandular tissue, and a kernel of 3 by 3 pixels is used to search the hot spot. The hotspot enhancement is 2 fold higher compared to the mean background tissue enhancement. A negative correlation with age was found (r=0.35 for hotspot, r=0.33 for mean tissue enhancement). The presented method may be used to evaluate the role of background tissue enhancement as a risk factor in development of contralateral breast cancer.

Keywords

accuracy adjustment affect amount applied asymptomatic automatic averaging background breast cancer clear clinical coefficient color computer connecting contained contour contrast correlated correlation course criterion cycle days decreased degree demonstrating denotes dense density detection developing development diagnosed diagnosing diagnosis diagnostic divided dynamic enhanced enhancement enhancements ensure entire established evaluating examination examining examples extent facilitate fatty fold frame frames functional furthermore gradient green highest hormone identified illustrated incidental included increasing injection intensities intensity investigate isolated kernel king largest likely lowest marked measure measured medical menopausal menstrual mild minimal minimize modality moderate monitoring negative noted operative outlined outlining panel patients percent peter physics piece pixel pixels post precise program radiology ranging received recent recommended relationships remained resolution respectively risk role scanner screening search segmentation segmented sensitivity significantly since spot staging starting strong subjects subtraction supply surgery table taken temporal therapy tissue tissues treatment trend tumor vascular vessels whole woman women year years yield younger