Meeting Banner
Abstract #3250

On the Spatial Distribution of Cerebrovascular Reactivity During Breath Hold and CO2 Inhalation Tasks as Assessed by Data-Driven Analysis Methods

Ekaterina Tchistiakova1, 2, David E. Crane3, Jeremy Gilbert4, Sandra E. Black3, 5, Bradley J. MacIntosh1, 3

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Heart and Stroke Foundation Centre for Stroke Recovery,, Sunnybrook Research Institute, Toronto, Ontario, Canada; 3Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Research Institute, Toronto, Ontario, Canada; 4Department of Medicine, Division of Endocrinology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 5Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada

Cerebrovascular reactivity (CVR) can provide valuable information on hymodynamic impairment in a wide range of neurological conditions. In this study we compared the spatial distribution of CVR maps obtained using CO2 inhalation and breath hold (BH) tasks. The two hypercapnic challenges showed a good spatial overlap of CVR maps. Discrepancies were confined to inferior temporal and frontal pole regions with higher sensitivity during BH and CO2 respectively. CO2 CVR presented with increase in regions related to visual processing and sensorimotor areas compared to BH.

Abstract PDF Presentation Video

Keywords

achieved acquisition activation activity additional allele apparent approaches appropriate blood blue bold boluses brain breath calibration carriers cerebral challenge challenges characterize circuit clinical closely coefficient combined complications components conditions consisted convolved corrected correction correlated correlation correspondence crane datasets delay delays detected detection detract disease distinct distribution division double driven dual established estimation examination examined expiration feed flow forward foundation frontal functional fusiform future generated gilbert glover health heart highlights hold holding hypertension identified identify impede incorporating induced inferior inhalation linear mapping maps match matrix measure medicine melodic metrics model moderate motion network networks noise object orange overlapping oxygenation paired participant participants patterns period permutation pole population preexisting proper protocol reactivity recognition recovery reduced reflect regression related resolution respectively response revealed risk sciences sensitivity separately several severe significantly slice slices software spatial stats stroke subject system task tasks temporal threshold twelve type underwent variance variation vascular visual volumes whereby wise yellow young