Meeting Banner
Abstract #3221

The Relationship Between Neurotransmitter Levels, BOLD Changes and Neural Oscillations in Primary Motor Cortex.

Mary C. Stephenson1, SoYoung Kim2, Matthew J. Brookes1, Steve Jackson2, Peter G. Morris1

1School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2School of Psychology, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

While functional Magnetic Resonance Imaging (fMRI) is an extremely useful tool for investigating functional changes and connectivity in the brain, the exact mechanisms underlying the signal is unclear. In this study we have related stimulus induced (SI) BOLD changes to neural oscillations measured using magnetoencephalography, and neurotransmitter levels, measured using magnetic resonance spectroscopy. We show that BOLD changes in M1 can be predicted by the amplitude of the post-movement &[beta]-rebound, and to the concentration of &[gamma]-aminobutyric acid (GABA). In addition we show that &[gamma]-band neural oscillations are related to both GABAergic and glutamatergic neurotransmission, whereas &[beta]-band changes are GABAergic.

Abstract PDF Presentation Video

Keywords

absolute activity addition advances afforded agreement agrees amplitude appear astronomy atlas averaging band bands basal basis better bold career cells central channel clench closely coil comprised computed concentration concentrations constructed contrast control corrected correlated correlation cortex cortical decrease decreased define delay dominant either electrical established evolution excitatory experiment extended filtered findings frequency functional generated glutamate hand handed hands healthy height implies indicates indicating induced influenced inhibition inhibitory isotropic kingdom known locations maps mask masked matched measured metabolic metabolite morris motion motor movement natural neural neurotransmitter origin oscillations oscillatory output overlapping oxygen pairs paradigm parametric part pass peak period peter physics plot pool positive post power predict predicted previous primary product projected pyramidal quantify rebound related relationship respective responses rest resting school screen sense separately significantly since smoothed source space spectra spectral statistical stimulation stimulus studies subject subjects suggesting suppressed synaptic system tasks took trust unclench underlying variation visual volume whether word