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Abstract #3211

Impact of Accuracy and Reliability of Diffusivity in Assessing Acute Ischemic Stroke

Venkata Veerendranadh Chebrolu1, Dattesh D. Shanbhag2, Ek Tsoon Tan3, Patrice Hervo4, Marc-Antoine Labeyrie5, Catherine Oppenheim5, 6, Rakesh Mullick2

1Medical Image Analysis Lab, GE Global Research, Bangalore , Karnataka, India; 2Medical Image Analysis Lab, GE Global Research, Bangalore, Karnataka, India; 3GE Global Research, Niskayuna, NY, India; 4GE Healthcare, Buc, France; 5Departments of Radiology and Neurology, Centre Hospitalier, Sainte-Anne, Paris, France; 6Universit Paris Descartes , Paris, France

The b-factor used for DWI imaging could vary due to factors such as gradient non-linearity and concomitant field effects. These system imperfections may differ between different vendors and MRI systems. This variation would impact multi-center studies evaluating the efficacy of the PDM criteria for thrombolysis treatment decision. In this work we demonstrate that in presence of b-factor variability a joint DWI and ADC based method may offer more robust perfusion-diffusion mismatch assessment compared to ADC alone based DWI lesion segmentation method.

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Keywords

accuracy accurate acquisition acute agreement alone anterior apparent apply assessment audience automated axial baron basis better brain called channel clinical coefficient cohort coil complete computations compute computed concomitant considered contrast core coronal criteria decay decision decisions define depend described determination developed differ diffusion dimension efficacy element encoding equation error evaluating experienced exponential field final forms generate global gradient ground guide head hence hours impact imperfections include included indicate intensities intensity interestingly joint lesion lesions linearity magnetization maps marked mask matrix measured measures medical mismatch modifications modified morphological neurology oblique offer onset open perfusion physicists potential processed radiologist radiologists radiology radius realized reliability remove repeated represent respectively robust robustness scanner segmentation sensitivity sets several shape similarly slice slices spatial stability statistical statistically statistics step stroke strong studies suggests susceptibility synthesized system systems target theory threshold tool trace transverse treatment truth typical unit variability variation variations vary varying view volume volumes workstation zero