Meeting Banner
Abstract #3190

Application of Multi-Tensor Tract-Based Analysis (MTTA) with Routine Clinical Diffusion MRI

Virendra Mishra1, Hao Huang1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Single tensor fractional anisotropy (FA) values are significantly underestimated at the crossing-fiber regions. Single tensor FA, therefore, is biased in characterizing white matter integrity in clinical research. Tract analysis has obtained recent attention as individual white matter tracts have more clinical significance. In this abstract, we further explored an MTTA technique capable of restoring the FA values of the targeted tract along its path while correcting the bias in single tensor FA. Specifically, we directly tested MTTA with in vivo diffusion MRI acquired in routine clinical research and proposed weighted FA at the crossing-fiber voxels as an unbiased anisotropy metric.

Abstract PDF Presentation Video

Keywords

achieved acquisition addition alignment anisotropy application applied applying arrows asterisks attention audience avoid axial bias biased blue bottom brain bundle characterize characterizing circle circumstances clinical columns component consistent contrast control convergence correct corrected correcting correction criteria crossing decomposition defined degrees derived detecting determined diffusion digital disorders eigenvectors energy ensure entire error essentially extensive fact fiber fibers fitted fitting fractional fractions frontal gradient harmonics healthy homogeneous identification in vivo indicated indicates individual inferior integrity known local longitudinal matrix measure measured measures metric metrics minutes mixture model neurological optimized orientations overlaid overlap panel panels path paths phantom pink potential previous program proposed psychiatric psychological quality quantify readily recent reduction renders representative representing require resolution restore restores routine sampled scanned scanners scheme selected sense sensitivity several severely shot significance significantly simplified simply slices southwestern structural subjects summary superior surrounding system target targeted tensor tensors traced tract tracts typical unbiased underestimated upper validation volunteers white yellow young